In January 2020 the 5-year EU funded EPHOR (Exposome Project for Health and Occupational Research) project will be launched, which TNO leads. Here we will lay the groundwork for evidence-based and cost-effective prevention to improve health at work by developing a working-life exposome toolbox. By joining forces in this exceptional consortium of exposure, health and data scientists and technology partners (19 partners in 12 countries, see map) we will advance occupational health science in a unique way to reduce the burden of disease.