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Candidate List updated with eight hazardous chemicals


Helsinki, 8 July 2021 – Some of the newly added substances are used in consumer products, such as cosmetics, scented articles, rubber and textiles. Others are used, for example, as solvents, flame retardants or in the manufacture of plastics products. Most of them were added to the Candidate List due to their hazards to people, being toxic for reproduction, carcinogenic, respiratory sensitizers or endocrine disruptors.  


Companies must follow their legal obligations and ensure the safe use of these chemicals. They also have to notify ECHA under the Waste Framework Directive if their products contain substances of very high concern. This notification is submitted to ECHA’s SCIP database and the information will later be published on the Agency’s website.


Entries added to the Candidate List on 8 July 2021:

Substance name



Reason for inclusion

Examples of use(s)

2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers

Toxic for reproduction (Article 57 (c)) 

Cleaning agents, cosmetics, in scented articles, polishes and wax blends.

Orthoboric acid, sodium salt



Toxic for reproduction (Article 57 (c)) 

Not registered under REACH. May be used as solvent and corrosion inhibitor.

2,2-bis(bromomethyl)propane1,3-diol (BMP);

2,2-dimethylpropan-1-ol, tribromo derivative/3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA);

2,3-dibromo-1-propanol (2,3-DBPA)








Carcinogenic (Article 57 (a)) 

BMP: manufacture of polymer resins and in one component foam (OCPF) application.

TBNPA: polymer production manufacture of plastics products, including compounding and conversion and as an intermediate.

DBPA: registered as an intermediate.




Respiratory sensitising properties (Article 57(f) – human health)

Biocides, leather tanning, x-ray film processing, cosmetics.

Medium-chain chlorinated paraffins (MCCP) UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17

PBT (Article 57 (d)) vPvB (Article 57 (e))

Flame retardants, plasticising additives in plastics, sealants, rubber and textiles

Phenol, alkylation products (mainly in para position) with C12-rich branched alkyl chains from oligomerisation, covering any individual isomers and/ or combinations thereof (PDDP)

Toxic for reproduction (Article 57 (c)) Endocrine disrupting properties (Article 57 (f) – human health and environment)

Preparation of lubricant additive materials and of fuel system cleaners.




Carcinogenic (Article 57 (a)) Equivalent level of concern having probable serious effects to the environment (Article 57 (f) -environment) Equivalent level of concern having probable serious effects to human health (Article 57 (f) –human health)





Endocrine disrupting properties (Article 57 (f) – human health and environment)

Not registered under REACH. May be used in manufacture of phenolic and polycarbonate resin.


The Candidate List of substances of very high concern now contains 219 chemicals that may harm people or the environment. 

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